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1

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

Nina Klee, Pui Ee Wong, Beatriz Baragaña, Farah El Mazouni, Margaret A. Phillips, Michael P. Barrett, Ian H. Gilbert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 295 KB

english, 2010

2

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria Parasite Plasmodium falciparum

Phillips, Margaret A., Gujjar, Ramesh, Malmquist, Nicholas A., White, John, El Mazouni, Farah, Baldwin, Jeffrey, Rathod, Pradipsinh K.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 531 KB

english, 2008

3

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

Coteron, Jose M., Marco, María, Esquivias, Jorge, Deng, Xiaoyi, White, Karen L., White, John, Koltun, Maria, El Mazouni, Farah, Kokkonda, Sreekanth, Katneni, Kasiram

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.72 MB

english, 2011

4

Ectopie thyroïdienne chez l’enfant

Z. El Mazouni, I. El Wadeh, A. Gaouzi

Journal:

Journal de Pédiatrie et de Puériculture

Year:

2011

Language:

french

File:

PDF, 211 KB

french, 2011

5

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice

Gujjar, Ramesh, El Mazouni, Farah, White, Karen L., White, John, Creason, Sharon, Shackleford, David M., Deng, Xiaoyi, Charman, William N., Bathurst, Ian, Burrows, Jeremy

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.55 MB

english, 2011

6

P185 - Dyslipidémie et risque cardio-vasculaire chez le diabétique de type 2

A. Oulahiane, N. El Haddad, Z. El Mazouni, H. Iraqi, M.-H. Gharbi, A. Chraibi

Journal:

Diabetes & Metabolism

Year:

2011

Language:

french

File:

PDF, 57 KB

french, 2011

7

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

Gujjar, Ramesh, Marwaha, Alka, El Mazouni, Farah, White, John, White, Karen L., Creason, Sharon, Shackleford, David M., Baldwin, Jeffrey, Charman, William N., Buckner, Frederick S., Charman, Susan, Ra

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 219 KB

english, 2009

8

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N., Kaminsky, Werner, Charman, Susan A., Matthews, David, Rathod, Pradipsinh K., Phillips, Margaret A.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.84 MB

english, 2014

9

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

Deng, X., Gujjar, R., El Mazouni, F., Kaminsky, W., Malmquist, N. A., Goldsmith, E. J., Rathod, P. K., Phillips, M. A.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 3.04 MB

english, 2009

10

Original 2-(3-Alkoxy-1 H -pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Lucas-Hourani, Marianne, Munier-Lehmann, Hélène, El Mazouni, Farah, Malmquist, Nicholas A., Harpon, Jane, Coutant, Eloi P., Guillou, Sandrine, Helynck, Olivier, Noel, Anne, Scherf, Artur, Phillips, Ma

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.38 MB

english, 2015

11

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Phillips, M. A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng

Journal:

Science Translational Medicine

Year:

2015

Language:

english

File:

PDF, 934 KB

english, 2015

12

Le syndrome de Means à propos d’un cas

Sellay, S., Mazouni, Z. El, Rifai, K., Labied, A., Chraibi, A.

Journal:

Annales d'Endocrinologie

Year:

2015

Language:

french

File:

PDF, 52 KB

french, 2015

13

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

Pavadai, Elumalai, El Mazouni, Farah, Wittlin, Sergio, de Kock, Carmen, Phillips, Margaret A., Chibale, Kelly

Journal:

Journal of Chemical Information and Modeling

Year:

2016

Language:

english

File:

PDF, 8.49 MB

english, 2016

14

Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidines targeting Plasmodium falciparum dihydroorotate dehydrogenase display potent and selective antimalarial activity

Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L., Coterón, Jose M., Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani,

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.43 MB

english, 2016

15

Projections of Veronese surface and morphisms from projective plane to Grassmannian

A EL MAZOUNI,F LAYTIMI,D S NAGARAJ

Journal:

Proceedings Mathematical Sciences

Year:

2017

Language:

english

File:

PDF, 170 KB

english, 2017

16

NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex

Cukier, Cyprian D., Tourdes, Audrey, El-Mazouni, Dounia, Guillet, Valérie, Nomme, Julian, Mourey, Lionel, Milon, Alain, Merdes, Andreas, Gervais, Virginie

Journal:

Protein Science

Year:

2017

Language:

english

File:

PDF, 1.47 MB

english, 2017

17

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L., White, John, Shackleford, David M., Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T., Garcia-Pérez, Ado

Journal:

Year:

2018

Language:

english

File:

PDF, 1.55 MB

english, 2018

18

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

White, John, dhingra, satish, Deng, Xiaoyi, El Mazouni, Farah, Lee, Marcus, Afanador, Gustavo, Lawong, Aloysus, Tomchick, Diana R, Ng, Caroline L., Bath, Jade, Rathod, Pradipsinh K, Fidock, David A, P

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 2.11 MB

english, 2018

19

Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria

Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L., El Mazouni, Farah, White, John, Shackleford, David M., Katneni, Kasiram, Chiu, Francis C.K., Barker, Helena, McLaren, Jenna, Crighton, Elly, Chen, G

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 1.31 MB

english, 2020